Reports: Rolling Stones guitarist Wood ties knot






LONDON (AP) — Two British newspapers say Rolling Stones guitarist Ronnie Wood has married his fiancee Sally Humphreys at a ceremony at London‘s Dorchester Hotel.


The Sun and the Daily Mirror carried photographs of the 65-year-old rocker with a pale boutonniere and a dark blue suit, and his 34-year-old bride in a traditional white gown and a clutch of matching white flowers.






The Sun quoted Wood as saying “I’m feeling great” as he and his bride kissed and posed for pictures outside the exclusive hotel in London’s upscale Mayfair district.


The newspapers said the guests included singer Rod Stewart and his wife Penny Lancaster as well as ex-Beatle Paul McCartney and his wife Nancy Shevell.


A call and an email to Wood’s U.S.-based agent weren’t immediately returned Saturday.


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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct


C.J. Gunther for The New York Times


Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.







For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.




Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.


No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.


And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”


At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.


Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.


“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.


The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.


The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”


Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.


Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.


The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?


In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.


But Nutlins did not work as drugs because they were not absorbed into the body.


Roche, Merck and Sanofi persevered, testing thousands of molecules.


At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.


The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.


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Emanuel explores Midway privatization









Mayor Rahm Emanuel's administration will explore the possibility of privatizing Midway Airport but will take a shorter-term, more tightly controlled approach than was employed by former Mayor Richard Daley's team on the city's first go-round.

Chicago's last try, a 99-year lease that would have brought in $2.5 billion, died in 2009 when the financial markets froze up.

The city's latest intentions are expected to be formally announced Friday, ahead of a Dec. 31 deadline for deciding whether to retain a slot for Midway in the Federal Aviation Administration's airport privatization pilot program. The city put off this decision several times previously.

The move, preliminary as it is, is sure to be politically charged, given the anger over the way Daley's 75-year parking meter privatization deal has played out, with proceeds used to plug operating deficits and meter rates rising sharply.

With that historical backdrop, Emanuel is suggesting a more conservative approach. It includes a shorter-term lease of less than 40 years; a "travelers' bill of rights" aimed at ensuring any changes will benefit passengers; and a continuing stream of revenue for the city, giving it a shot to capture some growth.

And unlike the parking meter and Chicago Skyway lease deals, a new Midway transaction would not allow proceeds to be used to plug operating deficits or to pay for operations in any way, Emanuel said in an interview Thursday.

"I will not let the city use it as a crutch to not make the tough decisions on the budget," he said.

But while a shorter lease and greater city control may play well locally, those sorts of terms may not appeal to investors, experts said in interviews this month.

"The shorter the lease term, the lower the bid prices are going to be — that's just the math," said Steve Steckler, chairman of the Infrastructure Management Group, a Bethesda, Md.-based company that advises infrastructure owners and operators. "I'd be shocked if investors offered more than $2 billion for a 40-year lease," Steckler said.

Emanuel said: "Nobody knows until you talk to people. … I'm the mayor and I'm not agreeing to … 99 years. I'm saying it's either 40 years or less." His office has not offered an estimate of what such a deal could bring in, saying it would be premature.

"No final decisions have been made, but we can't make a decision until we evaluate fully if this could be a win for Chicagoans," Emanuel said.

A private operator would take over management of such revenue-producing activities as food, beverage and car rental concessions and parking lots. The FAA would continue to provide air traffic control, while the Transportation Security Administration would continue to provide security operations. The city would retain ownership.

Few details were provided about how privatization would affect travelers and Midway employees. Emanuel said specifics will emerge over time.

By year's end, the city will send the FAA a preliminary application, a timetable and a draft "request for qualification," a document the city will put out early next year to identify qualified bidders for the project. A review of the potential bidders will be conducted in the spring.

Last year, Emanuel expressed hesitation in pursuing a private lease for Midway unless a careful vetting process was in place, saying taxpayers were correct to be wary, given the city's history.

The evaluation process will be deliberate and open to public view, he said Thursday.

He pledged to create a committee of business, labor and civic leaders that will provide updates to the public on a regular basis and that will select an independent adviser to vet the transaction. The committee will deliver a report to the City Council, and there will be a 30-day review period before any vote.

"I set up a different process and a different set of principles that stand in stark contrast to what was discussed or done in the past," Emanuel said.

The FAA pilot program frees cities from regulations that require airport revenue to be used for airport purposes. It allows money to be withdrawn for other uses.

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Metra to install defibrillators throughout system













 


 
(Tribune illustration / March 13, 2012)


























































Hundreds of defibrillators will be installed on all of Metra’s trains, officials said today.

The commuter rail line plans to equip its trains with nearly 300 of the automatic external defibrillators, according to a news release.

Another 125 of the devices will be installed “throughout work facilities and Metra police vehicles,” the release said.

Metra is partnering in the effort with Northwestern Memorial Hospital, the Northwestern University Feinberg School of Medicine and Cardiac Science.

chicagobreaking@tribune.com
Twitter: @ChicagoBreaking




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Brain Benefits for the Holidays? Stuff the Stocking with Video Games









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‘So You Think You Can Dance’ Hoofs It Into a 10th Season






LOS ANGELES (TheWrap.com) – Put on your dancing shoes; “So You Think You Can Dance” has been given a 10th season, Fox said Thursday.


Auditions for the upcoming season will begin January 18 in Austin, Texas, before moving on to Detroit, Boston, Los Angeles and Memphis.






Fox’s president of alternative programming Mike Darnell praised “SYTYCD” creator Nigel Lythgoe in announcing the renewal.


“I couldn’t be more proud of the amazing work that Nigel and the entire ‘So You Think You Can Dance’ team has done over the past nine seasons,” Darnell said. “This show is truly one of the most compelling series on television and I can’t wait to bring it back for Season 10.”


Last season, the series underwent a format shakeup after Fox cut the show from two nights a week to one, eliminating the results shows.


Fox did not say when the new season of “So You Think You Can Dance” will premiere.


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Emanuel explores Midway privatization









Mayor Rahm Emanuel's administration will explore the possibility of privatizing Midway Airport but will take a shorter-term, more tightly controlled approach than was employed by former Mayor Richard Daley's team on the city's first go-round.

Chicago's last try, a 99-year lease that would have brought in $2.5 billion, died in 2009 when the financial markets froze up.

The city's latest intentions are expected to be formally announced Friday, ahead of a Dec. 31 deadline for deciding whether to retain a slot for Midway in the Federal Aviation Administration's airport privatization pilot program. The city put off this decision several times previously.

The move, preliminary as it is, is sure to be politically charged, given the anger over the way Daley's 75-year parking meter privatization deal has played out, with proceeds used to plug operating deficits and meter rates rising sharply.

With that historical backdrop, Emanuel is suggesting a more conservative approach. It includes a shorter-term lease of less than 40 years; a "travelers' bill of rights" aimed at ensuring any changes will benefit passengers; and a continuing stream of revenue for the city, giving it a shot to capture some growth.

And unlike the parking meter and Chicago Skyway lease deals, a new Midway transaction would not allow proceeds to be used to plug operating deficits or to pay for operations in any way, Emanuel said in an interview Thursday.

"I will not let the city use it as a crutch to not make the tough decisions on the budget," he said.

But while a shorter lease and greater city control may play well locally, those sorts of terms may not appeal to investors, experts said in interviews this month.

"The shorter the lease term, the lower the bid prices are going to be — that's just the math," said Steve Steckler, chairman of the Infrastructure Management Group, a Bethesda, Md.-based company that advises infrastructure owners and operators. "I'd be shocked if investors offered more than $2 billion for a 40-year lease," Steckler said.

Emanuel said: "Nobody knows until you talk to people. … I'm the mayor and I'm not agreeing to … 99 years. I'm saying it's either 40 years or less." His office has not offered an estimate of what such a deal could bring in, saying it would be premature.

"No final decisions have been made, but we can't make a decision until we evaluate fully if this could be a win for Chicagoans," Emanuel said.

A private operator would take over management of such revenue-producing activities as food, beverage and car rental concessions and parking lots. The FAA would continue to provide air traffic control, while the Transportation Security Administration would continue to provide security operations. The city would retain ownership.

Few details were provided about how privatization would affect travelers and Midway employees. Emanuel said specifics will emerge over time.

By year's end, the city will send the FAA a preliminary application, a timetable and a draft "request for qualification," a document the city will put out early next year to identify qualified bidders for the project. A review of the potential bidders will be conducted in the spring.

Last year, Emanuel expressed hesitation in pursuing a private lease for Midway unless a careful vetting process was in place, saying taxpayers were correct to be wary, given the city's history.

The evaluation process will be deliberate and open to public view, he said Thursday.

He pledged to create a committee of business, labor and civic leaders that will provide updates to the public on a regular basis and that will select an independent adviser to vet the transaction. The committee will deliver a report to the City Council, and there will be a 30-day review period before any vote.

"I set up a different process and a different set of principles that stand in stark contrast to what was discussed or done in the past," Emanuel said.

The FAA pilot program frees cities from regulations that require airport revenue to be used for airport purposes. It allows money to be withdrawn for other uses.

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Meteorologist: 'Stronger winds trumps the snow'









The first winter storm of the season is moving in fast and has hit the north and western suburbs with a fury as downed power lines were reported in McHenry County. 


Around 5 p.m., ComEd officials said more than 24,000 people were without power, most of those in the western Illinois region, like Rockford , Freeport and Dixon. At 5:35 p.m., less than an inch of snow was on the ground in Elburn.


A spokeswoman with ComEd said a few customers from Woodstock were powerless, but there weren’t any “significant” outages in that area.





Snow first hit Chicago around 5:30 p.m., when O’Hare airport reported seeing flurries, according to the National Weather Service. The snow will continue on throughout the evening, with a possible uptick around 9 p.m. or 10 p.m., meteorologists said.


Also, 30 to 40 mph winds have been reported with gusts as high as nearly 60 mph, said Ed Fenelon, a meteorologist with the National Weather Service.


“That trend is going to be continuing and some of the stronger winds will work their way“ to Chicago, Fenelon said. “That probably really trumps the snow as far as what kind of impact you can have.”


Hundreds of flights were canceled at O'Hare and Midway airports on the eve of the busiest travel day of the holiday season. Southwest Airlines scratched all of its flights scheduled after 4:30 p.m. today at Midway. People are being warned to stay off highways because high winds could whip up near blizzard conditions.


Delays at O’Hare were averaging 30 to 90 minutes, according to the FAA. Midway-bound flight delays were about 15 minutes or less.


At 6 p.m., a few crashes had been reported on roadways including I-290 at St. Charles Road and the inbound Edens Expressway at Tower Road.


The heaviest snow is expected to fall from 5 p.m. to 9 p.m. Three to 7 inches is expected in the far northwest suburbs, 2 to 4 inches in Chicago and 1 to 3 inches in the south and southwest suburbs.


The weather service says the winds will be the real problem. "We may not get a whole lot of snow but the potential for snowing, drifting and poor visibility is very high," weather service meteorologist Mark Ratzer said.

In its storm warning, the weather service said the greatest chance of near white-out conditions is near the shoreline in Lake and Porter counties in Indiana. The storm warning is in effect for those areas until 3 a.m. Friday.

In western Illinois and Wisconsin, a blizzard warning is in effect with as much as a foot of snow forecast. Snow could fall 1 to 2 inches an hour around Rockford, the weather service said.

To the south, a high wind advisory has been issued for Kankakee County.

The storm ends a record stretch of 290 days without snow in the Chicago area. This will also be the latest the city has seen its first measurable snowfall.


"It's going to be a shock to the system," said weather service meteorologist Ed Fenelon. "It's coming in with a bang."


ComEd said it was bracing for power outages due to the weather. The company said it was preparing additional crews and equipment and asking for help from other utilities to respond quickly to outages.

ComEd Vice President Terence Donnelly said the storm was “expected to be especially damaging” to the company's power system because of the combination of wind, snow and ice.


The Illinois Toll Highway Authority urged motorists to stay off the highways.

"This weather event is expected to impact most of the tollway system – from Rockford to Chicago – resulting in rapidly deteriorating driving conditions across the entire region,” tollway executive director Kristi Lafleur.  “We urge everyone to stay off the roads this afternoon and evening, if possible, but if you must drive, slow down and allow plenty of extra time for the commute home.”


Illinois Transportation Secretary Ann Schneider also said that “motorists should think twice before venturing onto roadways” Thursday night and urged drivers and their passengers “to buckle up, slow down and allow plenty of extra time to reach your destination. And, please don’t crowd the snow plows.”

IDOT was mobilizing more than 550 snow plows responsible for roads in northern Illinois while the Illinois Tollway was preparing its full fleet of 182 snow plows to try and clear the 286-mile network of toll roads in 12 counties in northern Illinois.

If conditions become extreme, the Illinois State Police is urging drivers involved in minor accidents where no one is injured to exchange insurance and driver information.

The agencies also provide multiple ways to receive updates electronically. Non-tollroad information can be found at www.gettingaroundillinois.com. Real time conditions on tollroads are available at www.illinoistollway.com. Drivers also can sign up for Tollway Tweets at the website or at www.twitter.com.

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RIM loses BlackBerry subscribers for first time






TORONTO (AP) — Research In Motion‘s stock plunged in after-hours trading Thursday after the BlackBerry maker said it plans to change the way it charges fees.


RIM also announced that it lost subscribers for the first time in the latest quarter, as the global number of BlackBerry users dipped to 79 million.






In a rare positive sign, the Canadian company added to its cash position during the quarter as it prepared to launch new smartphones on Jan. 30. The new devices are deemed critical to the company’s survival.


RIM’s stock initially jumped more than 8 percent in after-hours trading on that news, but then fell $ 1.48, or 10.4 percent, to $ 12.65 after RIM said on a conference call that it won’t generate as much revenue from telecommunications carriers once it releases the new BlackBerry 10 platform.


RIM is changing the way it charges service fees, putting an important source of revenue at risk. RIM CEO Thorsten Heins said only subscribers who want enhanced security will pay fees under the new system.


“Other subscribers who do not utilize such services are expected to generate less or no service revenue,” Heins said. “The mix in level of service fees revenue will change going forward and will be under pressure over the next year during this transition.”


RIM’s stock had been on a three-month rally that has seen the stock more than double from its lowest level since 2003.


But Mike Walkley, an analyst with Canaccord Genuity, said BlackBerry 10 will change RIM’s services revenue model dramatically. He said that instead of getting about $ 6 per device each month from carriers and users RIM could get as little as zero.


“That’s what turned the stock from being up 10 percent to being down 10 percent,” Walkley said. “That’s been part of our worry. How do they come back with a new platform and get carriers to continue to share the higher revenue —which sounds like they are not going to— and then subsidize the phone to make it affordable for consumers and enterprises.”


“People are seeing that the services revenue has a lot of risk to it now with the BlackBerry 10 migration.”


Three months ago, RIM had 80 million subscribers. Analysts said the loss of 1 million subscribers was expected. Once coveted symbols of an always-connected lifestyle, BlackBerry phones have lost their luster to Apple’s iPhone and phones that run on Google’s Android software.


RIM is banking its future on its much-delayed BlackBerry 10 platform, which is meant to offer the multimedia, Internet browsing and apps experience that customers now demand.


“We believe the company has stabilized and will turn the corner in the next year,” Heins said. He noted that the company’s cash holdings grew by $ 600 million in the quarter to $ 2.9 billion, even after the funding of all its restructuring costs. RIM previously announced 5,000 layoffs this year.


Heins said subscribers in North America showed the largest decline, but said there is growth overseas.


Colin Gillis, an analyst with BGC Financial, said before the conference call that the company bought itself more time.


“It doesn’t mean (BlackBerry) 10 will gain traction. A lot of people said 10 would be DOA, but I don’t think that’s going to be the case,” he said.


Jefferies analyst Peter Misek also earlier called the results better than expected, noting that RIM added a significant amount of cash. RIM will need the money to advertise the new BlackBerrys and operating system.


Misek also called it a positive development that RIM said there would not be another delay to BlackBerry 10.


“The success or failure of this company will be on BlackBerry 10,” Misek said.


RIM posted net income of $ 14 million, or 3 cents per share for its fiscal third quarter, which ended Dec. 1. That compares with a profit of $ 265 million, or 51 cents per share, in the same quarter a year ago.


The latest figure includes a favorable tax settlement. Excluding that adjustment, RIM lost 22 cents per share. Analysts polled by FactSet were expecting a wider loss of 27 cents.


RIM reported revenue of $ 2.7 billion, down 47 percent from a year ago.


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Twitter post offers clue to The Civil Wars’ future






NASHVILLE, Tenn. (AP) — While there still remain questions about the future of The Civil Wars, there’s new music on the way.


Joy Williams, one half of the Grammy Award-winning duo with John Paul White, said Thursday during a Twitter chat that she was in the studio listening to new Civil Wars songs.






It’s a tantalizing clue to the future of the group, which appeared in doubt when a European tour unraveled last month due to “irreconcilable differences.”


At the time, the duo said it hoped to release an album in 2013. It’s not clear if Williams was referring Thursday to music for a new album or for a documentary score they have composed with T Bone Burnett. They’re also set to release an “Unplugged” session on iTunes on Jan. 15.


Nate Yetton, the group’s manager and Williams’ husband, had no comment — though he has supplied a few hints of his own by posting pictures of recording sessions on his Instagram account recently. The duo announced last summer it would be working with Charlie Peacock, who produced its gold-selling debut “Barton Hollow.” The photos do not show Williams or White, but one includes violin player Odessa Rose.


Rose says in an Instagram post: “Playing on the new Civil Wars record… Beautiful sounds.”


Even with its future in doubt, the duo continues to gather accolades. Williams and White are up for a Golden Globe on Jan. 13, and two Grammy Awards on Feb. 10, for their “The Hunger Games” soundtrack collaboration “Safe & Sound” with Taylor Swift.


Williams’ comments came during an installment of an artist interview series with Alison Sudol of A Fine Frenzy sponsored by The Recording Academy.


___


Online:


http://thecivilwars.com


___


Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott.


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